effect of resonant acoustic mixing on pharmaceutical

Effect of resonant acoustic mixing on pharmaceutical ...

Jul 01, 2016  Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricant (Osorio and Muzzio, 2015). However, changes in material properties of the final blend were observed.

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Effect of resonant acoustic mixing on pharmaceutical ...

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets Osorio, Juan, [email protected], Purdue University, United States; Sowrirajan, Koushik, FDA, United States; Muzzio, Fernando, Rutgers University, United States ABSTRACT The blending performance in a resonant acoustic mixer (RAM) was characterized.

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Effect of resonant acoustic mixing on pharmaceutical ...

The blending performance in a resonant acoustic mixer (RAM) was characterized. The system showed to be highly effective in blending low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricants. A summary of these results will be described and changes in material properties were observed. Those changes, and their effects on tablet characteristics, were also studied.

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Effect of resonant acoustic mixing on pharmaceutical ...

Request PDF Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low concentrations ...

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Evaluation of resonant acoustic mixing performance ...

Jul 01, 2015  In this paper, the goal is to evaluate the mixing performance of a new mixer, a resonant acoustic mixer (RAM), using common pharmaceutical powders. This mixer works on a different principle than those commonly used for pharmaceutical processing, using resonant vibration to induce fast motion and homogenization of powders.

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Effect of resonant acoustic mixing on pharmaceutical ...

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets Osorio, Juan, [email protected], Purdue University, United States; Sowrirajan, Koushik, FDA, United States; Muzzio, Fernando, Rutgers University, United States ABSTRACT The blending performance in a resonant acoustic mixer (RAM) was characterized.

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Controlled shear system and resonant acoustic mixing ...

Controlled shear system and resonant acoustic mixing: Effects on lubrication and flow properties of pharmaceutical blends. ... In this work, the effect of API’s (Active Pharmaceutical Ingredient ...

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What is ResonantAcoustic® Mixing? - Resodyn Acoustic Mixers

Dec 30, 2020  Fortunately, a new and innovative technology, ResonantAcoustic® Mixing (RAM), solves many of the problems that plague traditional mixers. RAM combines the efficient power generation of resonance and the effects of sound energy to facilitate mixing – without the use of impellers or other mechanical means within a mixing vessel.

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In-line and Real-time Monitoring of Resonant Acoustic ...

Run 1 – 4 for mixing process monitoring were prepared on the basis of the formulations in Table 2, and the mixing processes were monitored using the NIR method. Resonant acoustic mixing conditions The equipment used was a Resonant Acoustic LabRAM (Resodyn, MT), with the frequency fixed at 60 Hz. Table 2 shows each vibration force.

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Evaluation of resonant acoustic mixing performance ...

The mixing performance of a resonant acoustic mixer was characterized. • The resonant acoustic mixer reached minimum blend uniformity in as low as 30 s. • The temperature of the final blend increased with fill level, time and acceleration.

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Pharmaceutical co‐crystal: An alternative strategy for ...

Feb 04, 2021  6.7 Resonant acoustic mixing. Co‐crystal preparation relies on the acoustical transfer of mechanical energy to a wetted powder mixture (drug‐co‐former). This form of energy transfer encourages the intimate mixing of the components, therefore increasing

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Macro and micro characterization of powder mixing processes

The work presented in this dissertation focuses on the macro- and micro-mixing characterization of a resonant acoustic mixer (RAM), and the micro-mixing dynamic characterization of bin-blending for pharmaceutical powders, with an emphasis on mixing cohesive APIs. First, the mixing performance of the RAM as a function of processing parameters ...

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Fernando J. Muzzio Rutgers University, Chemical ...

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets. J.G. Osorio, K. Sowrirajan, F.J. Muzzio, Advanced Powder Technology 27 1141-1148 (2016). Enabling real time release testing by NIR prediction of dissolution of tablets made by Continuous Direct Compression (CDC). P.

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Evaluation of resonance acoustic mixing technology using ...

Evaluation of resonance acoustic mixing technology using ultra high performance concrete Aileen Vandenberga, Kay Willeb,⇑ a Civil and Environmental Engineering, University of Connecticut, 261 Glenbrook Road, Unit 3037, Storrs, CT 06269-3037, United States bDepartment of Civil and Environmental Engineering, University of Connecticut, United States ...

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(657a) Resonant Acoustic (Vibratory) Powder Mixing ...

Oct 20, 2011  Resonant acoustic mixing is known to significantly reduce mixing time making it a good candidate for improving the efficiency of powder mixing processes. The blend uniformity of lactose and acetaminophen powders blended using the RAM is compared to mixing results obtained using a double-cone tumble blender.

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Verification of the mixing processes of the active ...

Mixing processes are important for making high-quality pharmaceutical formulations and are related to dissolution and chemical stability in pharmaceutical manufacturing. The resonant acoustic® mixing (RAM) technology is a blending method, and it has been reported that it has a unique mixing action for various samples. In this study, in order to apply the RAM method to the pharmaceutical ...

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Ball-free mechanochemistry: in situ real-time monitoring ...

Mar 29, 2018  Resonant acoustic mixing (RAM) is a new technology designed for intensive mixing of powders that offers the capability to process powders with minimal damage to particles. This feature is particularly important for mixing impact-sensitive materials such as

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(PDF) PDF Polymer based calcium phosphate sca Rasiah ...

Academia is a platform for academics to share research papers.

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Dissertations / Theses: 'Stoke Poges' – Grafiati

Only in patients with moderate stroke longer time-to-treatment associates worse prognosis. 2) The effect of rt-PA on the likelihood of recanalization gradually decreases with time. Time-to-treatment longer than 270 min was independently associated with lower likelihood of recanalization. 23.

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Mixing by Controlled shear system and resonant acoustic ...

Sep 26, 2017  Purpose. Lubrication is critical in pharmaceutical manufacturing of solid dosage forms. The purpose of this paper is to systematically compare and correlate the lubrication effect of two devices, a controlled shear system and a Resonant Acoustic Mixer, on the flow properties of pharmaceutical

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(657a) Resonant Acoustic (Vibratory) Powder Mixing ...

Oct 20, 2011  Resonant acoustic mixing is known to significantly reduce mixing time making it a good candidate for improving the efficiency of powder mixing processes. The blend uniformity of lactose and acetaminophen powders blended using the RAM is compared to mixing results obtained using a double-cone tumble blender.

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Characterization of resonant acoustic mixing using near ...

Abstract This study presents the first investigations on the micro-mixing properties of pharmaceutical powder blends from a resonant acoustic mixer using near-infrared chemical imaging. All experiments were done in a laboratory resonant acoustic mixer (RAM). The powder blends were studied using near-infrared chemical imaging (NIR-CI). Qualitative (i.e. chemical images) and quantitative (e.g ...

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Evaluation of resonance acoustic mixing technology using ...

Evaluation of resonance acoustic mixing technology using ultra high performance concrete Aileen Vandenberga, Kay Willeb,⇑ a Civil and Environmental Engineering, University of Connecticut, 261 Glenbrook Road, Unit 3037, Storrs, CT 06269-3037, United States bDepartment of Civil and Environmental Engineering, University of Connecticut, United States ...

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Verification of the mixing processes of the active ...

Mixing processes are important for making high-quality pharmaceutical formulations and are related to dissolution and chemical stability in pharmaceutical manufacturing. The resonant acoustic® mixing (RAM) technology is a blending method, and it has been reported that it has a unique mixing action for various samples. In this study, in order to apply the RAM method to the pharmaceutical ...

get price

Complete Cocrystal Formation during Resonant Acoustic Wet ...

Jan 01, 2020  The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline–citric acid (THPCIT) cocrystal formation during the granulation process, thereby reducing the number of operations.

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Development and Scale-Up of Cocrystals Using Resonant ...

Jan 29, 2014  In the present work resonance acoustic mixing was applied to afford a practical and environmentally friendly approach to produce and scale up cocrystals. Scale-up options for producing cocrystals are limited. Solution-phase cocrystallizations, although amenable to scale-up in stirred tanks, may be limited due to multiple solubility constraints on both coformers and the product cocrystals ...

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Home - Resodyn Acoustic Mixers

Jun 02, 2021  ResonantAcoustic ® Mixing (RAM) Revealed. Discover the principles that drive RAM performance. From rapid vertical displacement to low frequency sound energy, and the “secrets” of resonance, RAM harnesses and combines common phenomena to introduce and deliver ground-breaking results to virtually any industry.

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RAM MIXER™ - PCCA

Resonant acoustic mixing ensures an even distribution of the active pharmaceutical ingredient (API) with repeatable results from mix to mix. It removes the human element from traditional mixing where potency results can be inconsistent depending on the pharmacist's or technician’s mixing techniques.

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(PDF) Using Multivariate Analysis for Pharmaceutical Drug ...

Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricant (Osorio and Muzzio, 2015).

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Influence of Material Properties on the Effectiveness of ...

Apr 16, 2018  Osorio J, Sowrirajan K, Muzzio F. Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets. Adv Powder Technol. 2016;27:1141–8. Article Google Scholar 22. Castellanos A. The relationship between attractive interparticle forces and bulk behaviour in dry and uncharged fine powders.

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Acoustic Mixing Patents - Resodyn Acoustic Mixers

Nano-suspension process - Merck Sharp Dohme Corp (2016) US Patent Number- 9,381,518. Pharmaceutical compositions that inhibit disproportionation - Merck Sharp Dohme Corp (2016) US Patent Number- 9,339,543. Preparing colorant dispersions using acoustic mixing - Xerox Corporation (2015) US Patent Number- 9,223,236.

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Juan OSORIO Postdoctoral Associate PhD Massachusetts ...

Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricant (Osorio and Muzzio, 2015).

get price

Ball-free mechanochemistry: in situ real-time monitoring ...

Mar 29, 2018  Resonant acoustic mixing (RAM) is a new technology designed for intensive mixing of powders that offers the capability to process powders with minimal damage to particles. This feature is particularly important for mixing impact-sensitive materials such as

get price